A consistently intelligent (or at least bright), coherently constructed comedy that is on occasion a rather pointed critique of the American education system in the…
"Osmosis Jones" is like the dark side of those animated educational films depicting the goings-on in the bowels. It takes us inside the human body for a tour of such uncharted neighborhoods as the Lower East Backside, and such useful organs as the Puke Button. These sights are depicted in colorful, gloppy, drippy animation, and then we switch to live action for the outside of the body in question, which belongs to a man named Frank (Bill Murray).
Frank follows the Ten-Second Rule, which teaches us that if food is dropped and stays on the ground less than 10 seconds, it's still safe to eat. In the case of the hard-boiled egg in question, he might also have reflected that before the egg dropped, he had to pry it from the mouth of a monkey. The egg is crawling with germs, sending the inside of his body into emergency mode.
At the cellular level, we meet Osmosis Jones (voice by Chris Rock), a maverick cop, always being called into the chief's office for a lecture. In the first animated microbiological version of a buddy movie, he teams up with Drix (David Hyde Pierce), a timed-release cold capsule, to fight the viral invasion, which threatens to kill Frank after Thrax (Laurence Fishburne) introduces a new and deadly infection.
The live action scenes, directed by Peter and Bobby Farrelly ("There's Something About Mary"), use Bill Murray's seedy insouciance as a horrible object lesson in what can happen to you if you don't think all the time about germs. His second, potentially lethal, infection comes as he visits a science fair where his daughter Shane (Elena Franklin) has an entry. Chatting with another entrant, he learns that the lad's experiment involves the cleansing of polluted oysters; assured that the oysters are cleansed, he eats one.